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We present the synthesis and biological evaluation of the prototype of a new class of cephalosporins, containing an additional isolated beta lactam ring with two phenyl substituents.This new compound is effective against Gram positive microorganisms, with a potency similar to that of ceftriaxone, a cephalosporin widely used in clinics and taken as
Drosophila melanogaster shows exquisite light sensitivity for modulation of circadian functions in vivo, yet the activities of the Drosophila circadian photopigment cryptochrome (CRY) have only been observed at high light levels.We studied intensity/duration parameters for light pulse induced circadian phase shifts under dim light conditions in viv
The observed spectral lags of gamma-ray bursts (GRBs) have been widely used to explore possible violations of Lorentz invariance.However, these studies were generally performed by concentrating on the rough time lag of a single highest-energy photon and ignoring the intrinsic time All Purpose Cleaning Brushes lag at the source.A new way to test non
ISG15 is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity.The role of ISG15 during bacterial infection remains elusive.We show that ISG15 expression in nonphagocytic cells is dramatically induced upon Listeria infection.Surprisingly this induction can be type I interferon independent and depends on the cytosolic